Bone marrow cell therapy after myocardial infarction. What should we select?
نویسنده
چکیده
This editorial refers to ‘Intracoronary infusion of bone marrow-derived selected CD34CXCR4 cells and nonselected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of the randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial’, by M. Tendera et al., on page 1313
منابع مشابه
Bone marrow mononuclear cell therapy for acute myocardial infarction: we know what we want, but we just don't know how yet.
To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implications for future directions in cell therapy for acute myocardial infarction. (Circ...
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INTRODUCTION AND OBJECTIVES Studies have shown that intracoronary infusion of mononuclear bone marrow cells improves ventricular function in patients with acute myocardial infarction. However, less information is available about the use of this therapy during the chronic phase of a myocardial infarction. This study involved an analysis of the clinical, echocardiographic and angiographic changes...
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The treatment of acute myocardial infarction (AMI) has evolved substantially over the past three decades, after an improvement in the mortality rate of AMI due to thrombolytics [1,2] and primary percu taneous intervention for coronary reperfusion [3]. Less than a decade ago, initial reports on the clinical application of mono nucleated bone marrow-derived stem cells (BMCs) in patients with AMI ...
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Remodeling of the left ventricle after myocardial infarction represents a major cause of infarct-related heart failure and death. Experimental data suggest that bone marrow-derived cells may contribute to the healing of myocardial infarction. The selective intracoronary transplantation of autologous, mononuclear bone marrow cells is safe and seems to be effective under clinical conditions conce...
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10 The time between myocar-dial infarction and intracoronary infusion therapy was nearly identical in the BMC and placebo group (median of 4 days), thus any spontaneous improvement in left ventri-cular ejection fraction (LVEF) prior to intra-coronary infusion therapy may have occurred to the same extent in both groups. As suggested by Marenzi and Bartor-elli, we re-analysed a potential effect o...
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ورودعنوان ژورنال:
- European heart journal
دوره 30 11 شماره
صفحات -
تاریخ انتشار 2009